When Blythe and her father move into the apartment above a pet shop, she discovers she can communicate with the animals, so she spends her free time helping out the store owner, Mr. Twombly.

After losing his wife seven years earlier, the eccentric Dr. John Dolittle, famed doctor and veterinarian of Queen Victoria's England, hides behind the walls of Dolittle Manor with only his menagerie of exotic animals for company. But when the young queen falls gravely ill, a reluctant Dolittle is forced to set sail on an epic adventure to a mythical island in search of a cure. The doctor is joined on his quest by a young, self-appointed apprentice...